Signs and symptoms of aTTP
The symptoms of aTTP are driven by microthrombi, which are unpredictable and potentially fatal1,2
Microthrombi can have serious acute and chronic consequences in TTP—putting patients at risk for devastating effects and death without urgent treatment.
Microthrombi can occur in any organ with microvessels, but the most commonly affected are3
Tissue and organ damage resulting from ischemia leads to increased levels of lactate dehydrogenase (LDH), troponins (heart), and creatinine (kidney).1,4
The signs and symptoms of TTP
Dr Marie Scully details the variable, complex signs and symptoms of TTP.
TTP patient case study
Dr Flora Peyvandi shares her experience with a 24-year-old female patient, underscoring the urgency and severe consequences of TTP when signs go unnoticed.
Signs and symptoms of acquired thrombotic thrombocytopenic purpura (aTTP) include1,4,5
Petechiae, purpura, bruising (skin)
Headache, confusion, seizures, coma (neurological)
EKG abnormalities (cardiac)
Abdominal pain, diarrhea (gastrointestinal)
of TTP episodes result in ischemia due to platelet aggregation in the microcirculation of the brain.3
The consequences of microthrombi can be severe, with TTP potentially resulting in acute thromboembolic events such as1,2,4
Long-term risks of TTP can be life-altering for patients. Thinking beyond the acute stages is imperative.
References: 1. Joly BS, Coppo P, Veyradier A. Thrombotic thrombocytopenic purpura. Blood. 2017;129(21):2836-2846. doi:10.1182/blood-2016-10-709857 2. Goel R, King KE, Takemoto CM, Ness PM, Tobian AAR. Prognostic risk-stratified score for predicting mortality in hospitalized patients with thrombotic thrombocytopenic purpura: nationally representative data from 2007 to 2012. Transfusion. 2016;56(6):1451-1458. doi:10.1111/trf.13586 3. Moake JL. Thrombotic thrombocytopenic purpura: the systemic clumping “plague.” Annu Rev Med. 2002;53:75-88. doi:10.1146/annurev.med.53.082901.103948 4. Scully M, Hunt BJ, Benjamin S, et al; British Committee for Standards in Haematology. Guidelines on the diagnosis and management of thrombotic thrombocytopenic purpura and other thrombotic microangiopathies. Br J Haematol. 2012;158(3):323-335. doi:10.1111/j.1365-2141.2012.09167.x 5. Azoulay E, Bauer PR, Mariotte E, et al; Nine-i Investigators. Expert statement on the ICU management of patients with thrombotic thrombocytopenic purpura. Intensive Care Med. 2019;45(11):1518-1539. doi:10.1007/s00134-019-05736-5